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Endnotes and References The efficacy estimand represents efficacy had all randomized participants remained on study intervention (with possible dose interruptions and/or dose modifications) for 52 weeks without initiating prohibited weight management treatments, and assuming participants who took rescue orforglipron would not have received any additional improvement from their randomized study treatment

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Presented for research literature review only Giugliano D et al

It is the most effective oral skin brightner available and has numerous other health benefits