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In addition, although statistical significance could not be calculated for values below detection limits, acetyl-CoA and ATP levels can be considered to have increased upon L-carnitine administration, which suggests that oxidation of lipids was enhanced to produce acetyl-CoA, resulting in ATP production (Table 1)

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One such enzyme is cystathionine beta-synthase (CBS), which catalyzes the first and most important (rate-limiting) step in trans-sulfuration from homocysteine to cystathionine

So, the route of administration matters

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