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Critical points are represented by the actual relevance of the mucus layer covering the epithelium of the nasopharynx, by the interaction of the meningococcus with the different cell types of the human nasopharynx and the local microbiota, and by the mechanism of invasion of the epithelium (intracellular or paracellular)
Based on a previous work, 30 mg/kg was considered the dose sufficient to achieve a C max comparable to the L-carnitine concentration used in vitro (1 mM) 41
Cost is another considerable aspect of feasibility for healthcare systems and providers
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These differences in preference, while straightforward, have meaningful implications for how broad the market for GLP-1s may ultimately become
This cold environment slows the breakdown of the active compound and preserves its molecular structure
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