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The latest findings further revealed that the HECT domain-containing ubiquitin E3 ligase HUWE1 was also an underlying protective modulator that could combat ferroptosis and abnormal iron accumulation by diminishing the amassing of TfR1, reducing the risk of ALF (Wu et al., 2022)

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Furthermore, GLP-1 receptor agonists induce anti-inflammatory effects that could attenuate the low-grade inflammation that underlies obesity, PsO, and HS (reviewed recently in the context of PsO and psoriatic arthritis).68 Finally, improved metabolic control and cardio-renal protection could be beneficial for reducing CVR and managing comorbidities such as DT2 or metabolic syndrome

Although there is promise demonstrated by FMTs in the realm of metabolic disorders in animals, further clinical trials are required to ascertain the effectiveness of this method for this specific indication [272]

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