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Both are dominated by dose-related gastrointestinal effects (nausea, diarrhea, constipation)

A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study was done to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of orforglipron

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When used with insulin or sulfonylureas, dose adjustments of these medications may be needed to reduce hypoglycaemia risk