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Palmoplantar pustular psoriasis is associated with missense variants in CARD14 , but not with loss-of-function mutations in IL36RN in European patients
Slower titration was associated with reduced severity
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When the body lacks sufficient B12, it can disrupt normal hair growth cycles and cause rampant shedding
That is a direct consequence of a half-life of roughly one week: one missed weekly dose does not produce washout, because roughly half the prior dose remains
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