Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification
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Animal data is a necessary first step, but its far from sufficient on its own to draw conclusions about a drugs effectiveness and safety in humans
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