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In addition, a 2026 systematic review found that GLP-1 medications produce greater weight loss in women than men, potentially due to the synergy between GLP-1 drugs and estrogens. However, Dr

This contributes to additional water retention, potentially obscuring muscle definition

Its a high-stakes change that can affect long-term outcomes, trigger weight regain, or introduce new side effects," McGowan said

(2025) reached the same conclusion, demonstrating that sertraline had almost no effect at low doses but affected virtually all of the tested parameters at supratherapeutic concentrations

Access to weight management medicines on the NHS is governed by NICE guidance and NHS England commissioning policies