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The most frequently reported adverse effects relate to the gastrointestinal system rather than direct cardiac effects, including nausea (occurring in approximately 15-20% of patients according to the SmPC), vomiting, diarrhoea, and constipation

2015;11: e1004917

Rickettsiosis subcommittee report to the tick-borne disease working group

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In practice, this may include complementary tandem mass spectrometry activation methods, such as higher-energy collisional dissociation alongside electron-transfer dissociation or electron-transfer and higher-energy collision dissociation, to avoid blind spots for labile modifications and to localise molecular changes with confidence

"I've got a left hook that could kill you," she told Oprah