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All experimental procedures involving animals were conducted following international recommendations for the care and use of laboratory animals, as well as the guidelines of the Brazilian Society of Neurosciences and Behavior for Animal Care
Only about 10% of the secreted GLP-1 is delivered to the pancreas in its active form, while the rest is rapidly converted to inactive metabolites
The reactive oxygen species (ROS) include, e.g., hydroxyl radicals, atomic oxygen, hydrogen peroxide, ozone, etc., while reactive nitrogen species (RNS) include mostly derivatives of nitrogen oxide such as nitrites, nitrates, and peroxynitrites
By conferring resistance to a number of chemotherapeutic drugs, an important 2004 study published in the Cell Biochemistry and Function highlights, Elevated levels of glutathione in tumor cells are able to protect such cells in bone marrow, breast, colon, larynx and lung cancers. The reverse is also true