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The GLP-1 drugs seemed to work across the board
For instance, in vitro studies using HepG2 cells treated with palmitic acid revealed that the GLP-1RA exendin-4 downregulated the expression of SREBP-1c and FAS, thereby attenuating steatosis ( de novo lipogenesis ( In summary, GLP-1 receptor agonists regulate hepatic lipid metabolism in MASLD through activation of AMPK-mediated fatty acid -oxidation, suppressing lipogenesis-related gene expression, and enhancing lipid export and autophagy
41(Suppl.)1720
The presence of ROS stimulates the production of GSH by increasing cystine uptake and promoting the expression of GCL 34
Diabetes Obes Metab (2016) 18:4919
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