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These results highlight semaglutides early action on decreasing major cardiovascular events, with significant benefits already evident by the first 6 months, and for some, even earlier, even before any major weight loss and before most patients would have been titrated to their full target dose of 2.4 mg, said lead author Dr Jorge Plutzky, Director of Preventive Cardiology, Cardiovascular Medicine at Brigham and Womens Hospital, Boston, MA, USA and a member of SELECT Steering Committee
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Lack of Clinical Data : The safety and efficacy data supporting tirzepatide use come exclusively from studies using FDA-approved formulations
The discontinuation rates due to adverse events, which were comparable to placebo, suggest that the transition to oral orforglipron is generally well-tolerated by patients already acclimated to incretin therapy
Connection Between Semaglutide and Kidney Health Semaglutide itself is not known to directly damage the kidneys in most people
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