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PMID: 20524875 [LoE A] [2] Weschawalit, S., Thongthip, S., Phutrakool, P., & Asawanonda, P
GIP receptor agonism amplifies insulin response, may reduce nausea at higher doses (a counterintuitive but documented effect), and appears to enhance the metabolic effects of GLP-1 agonism synergistically
"Tirzepatide effectively reduced drive to eat, as well as food-cue-driven and other-cue-driven eating behavior." Nature Medicine This effect is due to tirzepatides action on both GIP and GLP-1 receptors, which slows gastric emptying, signals fullness to the brain, and improves insulin sensitivity
Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
9 Because of these direct effects on the kidneys, nephrology guidance is now starting to position GLP-1 receptor agonists as kidney-protective therapy in their own right, not only as weight-loss or diabetes medications
Some areas offer specialist weight management services through multidisciplinary teams including dietitians, psychologists, and exercise specialists
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