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In a small clinical trial in patients with breast cancer taking tamoxifen 20-30 mg daily, adding curcumin 1200 mg plus piperine 10 mg three times daily reduces the 24-hour area under the curve of tamoxifen and the active metabolite endoxifen by 12.8% and 12.4%, respectively, as well as the maximum concentrations of tamoxifen, when compared with tamoxifen alone
Several cancer cell lines, including those derived from pancreatic cancer, glioblastoma multiforme and acute myelogenous leukemia, have also demonstrated sensitivity to glutamine starvation [1]
These medications are less commonly prescribed due to higher interaction risks