10.1023/B:AGEN.0000029390.09354.f8 Angiogenesis
Yes, typical protocols suggest starting at 200 mcg daily and gradually increasing the dose by about 200 mcg every two weeks, as tolerated, up to a maximum of 600 mcg daily
Two of the five residues are D-configured
How quickly you respond depends on: How low your B12 levels are How long symptoms have been present Your overall health Whether there are underlying absorption problems Whether repeat treatment is needed It is important to have realistic expectations
This includes SSRIs (such as Zoloft, Prozac, Celexa, and Paxil), SNRIs (such as Effexor and Savella), MAOIs, tricyclic antidepressants, and some mood stabilizers like lithium
Most protocols call for morning dosing, though the evidence for timing specificity is thin