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10.1111/adb.12583 27 HernandezN
GLP-1 (glucagon-like peptide-1) medications, like compounded semaglutide, mimic a natural hormone that helps regulate blood sugar, appetite, and metabolism
Ageing Res Rev 89:101979
10.1038/sj.ijo.0800818 73 PalmiterR
In a cohort of 3731 patients, weight loss of 5%, 10%, and 15% was observed in 63%, 33%, and 14%, respectively, after 56 weeks of treatment (27%, 11%, and 4% with placebo),69 or of an additional 6% at 56 weeks in patients who had already lost 6% through hypocaloric diet and exercise.70 Positive results were also observed in adolescent patients with obesity,71 and in real-life studies substantial weight loss has also been reported.7275 Phase 3 trials with GLP-1 receptor agonists indicated specifically for obesity and overweight
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