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In clinical trials of Zepbound, around 7% of people taking 15 mg of the drug, 6% of those taking 10 mg, and 5% of those taking 5 mg experienced fatigue, compared with only 3% of those taking a placebo
Starting low and going slow with dose titration reduces this risk meaningfully
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Special Considerations: Pregnancy Planning, Surgery, Kidney/Liver Issues Pregnancy: Because semaglutide clears slowly, most labels advise stopping at least 2 months before a planned pregnancy
Together they span repair, angiogenesis, matrix support and inflammation
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