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10.1002/ejic.201700183 119 PettinariR.CondelloF.MarchettiF.PettinariC.Bautista-ToledoM

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Taken together, the observed difference between neutralizing and non-neutralizing nanobodies seems to be a combination of high affinity and specificity to the prefusion form of gB, and the targeted epitope

That three-receptor approach is what separates it from Tirzepatide (dual agonist) and Semaglutide (single agonist), and the clinical data reflects that gap clearly