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Patients with specific FTO variants, for example, show a 2.8x greater tendency toward rapid weight regain and may benefit from indefinite maintenance therapy rather than attempting discontinuation

Take home message Despite not being prominently featured in medication guides, reports from Second Nature members and online forums suggest that cold sensitivity is a real and common experience among Mounjaro users

It binds to growthhormone secretagogue receptors (GHSR) in the hypothalamus and pituitary, reduces the inhibitory signal from somatostatin, and triggers a rapid GH pulse

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According to the report, parenteral accounted for the largest market share