does retatrutide lower a1c (not yet approved in US but people using anyway) promises even potentially greater weight loss amongst the GLP1 drugs. https://www.nejm.org/doi/full/10.1056/NEJMoa2301972 Retatrutide vs Semaglutide and Tirzepatide:

How long reconstituted PT-141 lasts Standard shelf life: 28-30 days refrigerated (conservative) Using bacteriostatic water (0.9% benzyl alcohol) Some users report 60-90 days with no noticeable potency loss Play it safe: Use within 30 days With sterile water (no preservative): Only 5-7 days maximum Bacterial growth risk higher Always use bacteriostatic water for PT-141 Sterile water not recommended Signs of degradation: Cloudiness (fresh PT-141 is clear) Particles or floaters Color change (PT-141 should be clear/colorless) Foul smell (fresh has no smell) Reduced effectiveness (subjective) Maximizing shelf life: Refrigerate immediately after reconstitution Never leave at room temp (degrades quickly) Minimize light exposure Clean stopper with alcohol before each access Don't contaminate with dirty needles Use within 30 days safest Planning reconstitution: PT-141 used "as needed" not daily 10mg vial lasts many doses (6-10 depending) Calculate how many uses within 30 days If infrequent user, reconstitute less at once Or accept some waste for convenience See how long reconstituted peptides last guide

But at the same time, like you say, we have around 50% of the worlds population being overweight or obese at this stage

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Enhancement of fracture healing with autogenous and allogene

Those deserve serious attention

Qsymia has been shown to have weight loss results that approach those of the lower doses of GLP-1 medications