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These chronic attributes are generally associated with selective degeneration of dopaminergic neurons, corollary de-pigmentation of substantia nigra pars compacta (SNpc) and concomitant accumulation of -synuclein in insoluble inclusions called Lewy bodies 2,3

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Therefore, GIP functions as a bifunctional regulator that stabilizes blood glucose and has diverging, glucose-dependent effects on the two main pancreatic glucoregulatory hormones (Christensen et al., 2011)

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