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Green PS, Mendez AJ, Jacob JS, Crowley JR, Growdon W, Hyman BT et al
Semaglutide activates only GLP-1 receptors, while tirzepatide (a GLP-1/GIP receptor agonist) engages dual pathways, often producing faster or more substantial weight lossup to 22% in clinical trials versus 15% for semaglutide alone
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The TRANSCEND-T2D-1 trial demonstrated A1C reductions of up to 2.0% and weight loss of up to 16.8% at 40 weeks, with no plateau observed through the end of the treatment period
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Similarly, tirzepatide is more effective at supporting weight loss than semaglutide but seems to have a poorer safety profile
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