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An alternative MSA-DH in vitro activity assay was developed which monitors the depletion of the aldehyde substrate using an MBTH-based approach (Figure 5B)
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As system Xc - is critical to provide cysteine for the biosynthesis of GSH [3], which is required for GPX4 activity [19], we hypothesized that ferroptosis susceptibility upon direct inhibition of GPX4 should not be affected by dexamethasone
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