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Adults over 65, people with cirrhosis, people taking corticosteroids or SSRIs, and pregnant people in the third trimester all have specific reasons to check before using an NSAID
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Use is most often described after age-related collagen decline becomes visible, commonly from the mid-30s onward
In a research context, the main limitations are the gap between animal and human data, stability sensitivity requiring proper storage, and the risk of compromised results if purity is not independently verified
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