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doi: 10.1186/S41927-022-00297-5/FIGURES/3 233 CeschiANosedaRPalinKVerhammeK

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Dependent on the TREM2-APOE pathway, microglia lose the expression of genes encoding homeostatic molecular profile (P2ry12, Tmem119, Csf1r, Hexb, Mertk, Cx3cr1) and upregulate the expression of inflammatory genes (Apoe, Itgax, Ccl2, Clec7a, Axl)