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1 Like most complex genomic regulatory systems, Nrf2 (nuclear factor erythroid 2-related factor 2) is sequestered in the cytoplasm until it is able to translocate into the nucleus, where it forms a heterodimer with MAF (another transcription factor) and binds to the promoter region of genes containing an antioxidant response element (ARE) sequence

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Further, they can decrease the expression of the VEGF, which suppresses angiogenesis, and they can inhibit matrix metalloproteinases (MMP-2, MMP-9) which inhibit the potential for metastasis (167)

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10.1007/s12031-018-1155-6 133 XuY.ZhangN.ChenC.XuX.LuoA.YanY.et al (2022)