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A 2025 systematic review by Vasireddi and colleagues in HSS Journal screened 544 published papers and identified 36 meeting inclusion criteria 35 preclinical studies and only one human study: an uncontrolled, unblinded, retrospective case series of 12 patients receiving intra-articular BPC-157 for chronic knee pain, in which 7 of 12 (58%) reported self-described relief lasting more than 6 months, with no dose, effect size, or systematically collected adverse events published
doi: 10.3390/pharmaceutics15020664 71 TatsutaMIishiHBabaMMikuniTNaraharaHUedoNet al
Medical contraindications and usewithcaution groups Even if regulators dont ban it outright, clinicians and safetyreview papers suggest avoiding or proceeding with extreme caution if you have: Active pancreatitis or high risk of pancreatitis Preclinical work links some GLP1like pathways (relevant to BPC157 formulations) with pancreatitis risk
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Ann N Y Acad Sci 1033:3041 Reuter SE, Evans AM (2012) Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspects
