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The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models

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95 Yamadera, H., Takahashi, K

The relationship between vitamin B12 and digestive health is particularly significant because the gastrointestinal tract is central to B12 absorption

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