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Other evidence also suggests that GLP-1R in the cerebral cortex affects hedonic feeding by targeting areas involved in reward and addiction (110)

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Safety and preliminary efficacy from the phase 1 portion of MasterKey-01: A First-in-human dose-escalation study to determine the recommended phase 2 dose (RP2D), pharmacokinetics (PK) and preliminary antitumor activity of BDTX-189, an inhibitor of allosteric ErbB mutations, in patients (pts) with advanced solid malignancies

This process is called dose escalation or titration

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