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A few of the most significant contributors to NAD+ depletion include: CD38: An enzyme that breaks down NAD+ and becomes more active with age, especially in response to inflammation
Dig Dis Sci 54:20702083 Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov D, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Aralica G, Stupnisek M, Suran J, Barisic I, Dzidic S, Vrcic H, Sebecic B (2014) Stable gastric pentadecapeptide BPC 157-NO-system relation
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