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Individual response varies due to genetic differences in receptor expression, baseline metabolic characteristics, pancreatic beta cell function, duration of diabetes, lifestyle factors, and adherence to dietary and physical activity recommendations

Analysis of mRNA from the aortas of different groups showed that FOXO4-DRI effectively inhibited the increase of pro-inflammatory factors such as Il-1 , Il-6 , Cxcl15 , and Tnf- (Figure 2B)