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Its exact mechanisms continue to be investigated
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
Moreover, the SURMOUNTMMO (tirzepatide, NCT05556512) will assess the impact of the dual GLP-1/GIP RA in cardiovascular outcomes and all-cause mortality for people with obesity (without diabetes) when the REDEFINE-3 study will assess the impact of cagrisema in people with obesity (with and without T2DM) and established cardiovascular disease
Rather than being a pharmaceutical development, this tripeptide occurs naturally in human blood plasma, with concentrations around 200 ng/mL at age 20 that decline to approximately 80 ng/mL by age 60
