Unlike previous studies that primarily focused on immune cell populations, our research emphasizes the complex interactions between multiple cell types, particularly vascular cellimmune cell crosstalk, providing deeper insights into how these interactions contribute to disease progression, especially in smoking-induced periodontitis
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267 GAS6, secreted by stromal cells such as CAFs and macrophages, binds to AXL, promoting its dimerization, autophosphorylation, and activation of downstream survival pathways, including the PI3K/AKT, MAPK/ERK, and NF-B pathways
Br J Haematol 2020;190:e2657 11
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