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Drug Discov Today 13 , 268274, doi:10.1016/j.drudis.2007.12.008 (2008)

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Previously asymptomatic patients present with hyperammonemic crises during triggers such as acute illness, gastrointestinal bleeding, high protein load, surgery, or medications such as sodium valproate

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Depression-related effects appear to be rare based on current clinical trial and post-marketing data