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Large randomized controlled trials in humans are absent, so clinical efficacy claims lack robust evidence

But insulin dose reduction needs to be done carefully and gradually, with close CGM monitoring, to avoid either hypoglycemia (from too much insulin relative to your new needs) or hyperglycemia (from reducing too aggressively)

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In both male and female GHRKO mice, disruption of the GH/IGF-1 axis from birth results in mice that are remarkably long lived, but temporal disruption of this pathway in young adults (aGHRKO mice) improves lifespan only in females 17 , an observation which is consistent with the beneficial effects of targeting IGF-1R signaling post-development on female healthspan and aging in this study

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Hereby, the suppression of inflammatory injury with GLP-1RAs treatment can be eliminated by 3-methyladenine/the mitochondrial kinase (PINK1) siRNA [141]