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Employer Responses: To manage costs, employers are more likely to reduce coverage or shift costs to employees, with 56% of large employers planning cost-cutting measures for 2026 compared to 48% in 2025
Conclusion: CT-388 was safe and tolerable, with no treatment-related discontinuations over 24w despite a rapid and steep up-titration to 22 mg, and delivered clinically meaningful WL and metabolic control in otherwise healthy adults with obesity
Taking folic acid supplements before getting pregnant and during early pregnancy can lower the chance of having a baby with a neural tube defect
For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results
96 Sabatini, S
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