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We have not only identified the engagement of active GLP-1R with ER-endosome MCSs, but also its localisation to VAPB-containing ERMCSs, from where endosomal GLP-1R assembles a newly described signalling nanodomain, enabling cAMP-dependent PKA activation at the OMM

165 Together, these researches suggest that lipid ectopic accumulation is directly correlated with IR