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Although these are promising results, evidence for a protective role for insulin remains low, and a recent Cochrane review from 2017 found no protective or preventive association between cognitive impairment and the use of antidiabetic T2D treatment strategies (Areosa Sastre et al., 2017) (i.e., metformin, insulin, repaglinide, glibenclamide, glimepiride, rosiglitazone, gliclazide, perindopril-indapamide )

Clinical Evidence: The STEP Trial Data Behind Approval The STEP program consisted of four randomized controlled trials enrolling over 4,500 participants

Approximately 5% of the adults with type 1 diabetes are in need of psychiatric treatment, the third level, which may involve psychotropic medication that can have an impact on glycaemic management

This was associated with the onset of metabolic disorders at an early stage, including insulin resistance, increased triglyceride levels and elevated leptin levels

The findings will pave the way for larger trials of these drugs