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Two approaches were used to assess a potential association between semaglutide and NAION: (1) an active-comparator cohort design (assessing outcomes of the new semaglutide users to the other drugs) and (2) a self-controlled case series (comparing risk during exposure vs
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This effect could lead to or exacerbate a condition called gastroparesis, which can cause symptoms such as abdominal pain and vomiting (2)
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The peptide is also studied in the context of energy expenditure pathways in cell and animal models
And that increase stems from just one medication, highlighting the outsized impact GLP-1s can have on overall health care costs
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