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The results imply that even residues not directly involved in the interaction may exhibit changes in their chemical environment if they are adjacent to residues crucial for the interaction or undergo conformational changes upon binding 39,40

Russian Khavinson V, Razumovsky M, Trofimova S, Grigorian R, Razumovskaya A

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One reason may be that bile acid production declines with age, leading to greater concentration of cholesterol in bile (Pak 2016)

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