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Significant differences between values were analyzed by two-way analysis of variance (ANOVA) followed by post hoc Tukeys multiple comparisons tests

GLP-1 based therapies have been shown to have anti-inflammatory effects in several organs, tissues and cells

In recent years, immunometabolism opens new therapeutic possibilities for the modulation of immune responses

In all the five studies, an oral (Delpres study via sublingual route) dose of 1000 g vitamin B 12 was used with the exception of Kuzminskis study, whereby a higher dose of 2000 g was used

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These results uncover a new mechanism through which AA-CDs mitigate OA and offer new insights on understanding the bioactivity mechanism of TCM-CDs