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Inter-individual variability in the absorption rate ( k a ), clearance (CL), intercompartmental clearance ( Q ), central volume ( V c ), and peripheral volume ( V p ) was explored using a log normal distribution in a model that included covariates with clear effects: drug product strength on the absorption rate constant and body weight as a covariate factor on CL, V c and V p
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Although this large, rigorous trial can provide support for a potential new indication for semaglutide for secondary prevention of CVD, whether and how quickly payers may reimburse for such an indication is uncertain
For CNS studies, GLP-1R knockout models or GLP-1R-negative cell lines as receptor-negative controls are essential