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Furthermore, quantification of hepatocellular vacuolation (a characteristic of cellular degeneration observed through tissue pathology staining) at the 2-h time point revealed a 1.5-fold greater area of liver degeneration in hepsin / mice compared with wild-type mice, which increased to ~ 2.5-fold greater by the 6-h time point (Fig
However, practical considerations exist regarding gastrointestinal tolerability
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Some 25 percent of people with MASH may go on to develop liver cirrhosis, permanent scarring that damages the organ, and liver cancer, both of which can cause organ failure
We never really saw obesity as a chronic disease
