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Mutations that lead to GS deficiency have been mapped onto the structure, providing a molecular basis for understanding their effects

Increased potassium conductance, which promotes neuronal stabilization

Prevalence of pigmentary disorders is also higher in people with darker skin, which sometimes makes it difficult to manage these cases

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The structure comprises the typical GST fold with an N-terminal thioredoxin-like domain ( 1 1 2 2 3 4 3 ) and an all-helical C-terminal domain ( 4 5 6 7 8 )