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The small GTPase Rab7 regulates the transport of autophagosomes and promotes their interaction with lysosomes (Wang et al., 2016)

Inhibition of the CCL2/CCR2 axis using a CCR2 inhibitor significantly increased paclitaxel sensitivity in both in vitro and in vivo models, suggesting that targeting this signaling pathway could be a promising therapeutic strategy to overcome chemoresistance in ovarian cancer

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