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IGF-1 LR3 works downstream, directly binding IGF-1R and bypassing both pituitary and liver feedback loops entirely

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Hormonal footprint documented Controlled human comparisons (for example, ghrelin vs GHRP-6 vs GHRP-2) showed GHRP-6 raises GH along with measurable ACTH, cortisol, and prolactin, separating it from the cleaner profile of ipamorelin

It has been used in dermatology for over three decades