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Chen LY, Mehta JL
At 26 weeks, mean percentage reductions in weight (the primary outcome) were 6.0 Percentage to 10.8 Percentage in the cagrilintide groups compared with 9.0 Percentage in the liraglutide group, and 3.0 Percentage with placebo [9]
The freeze-thaw cycle destroys peptide structure and eliminates therapeutic activity
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Drug-induced infertility
Bacterial expression produces none of those and instead produces host-cell protein, host-cell DNA, endotoxin from the Gram- negative cell wall, species with incorrect or scrambled disulfide pairing, N-terminal heterogeneity from incomplete or over-enthusiastic processing of the initiator methionine and the leader region, methionine oxidation, deamidation, clipped forms generated by host proteases, and covalent or non-covalent aggregate
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