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This effect was seen in both human intestinal and immune cells, as well as in mice with experimentally induced colitis, showing that taking KPV by mouth can reduce inflammation in the gut
NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin
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Petersburg Institute of Bioregulation and Gerontology and is published primarily in the Russian-language and English-translation journal Bulletin of Experimental Biology and Medicine
In diabetic nephropathy, depletion of endogenous polyamines contributes to podocyte injury, whereas exogenous spermine restores podocyte integrity by activating autophagy via the AMPKmTOR pathway, reducing apoptosis and glomerular damage 120
