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Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6
PMID: 28448947 Drucker DJ (2022): GLP-1 physiology informs the pharmacotherapy of obesity
its basic receptor biology
Missed periods lasting three or more months, heavy bleeding, or intermenstrual spotting should prompt a GP review, and pregnancy should always be excluded
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