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It also participates in the regulation of apoptosis pathways, with HSPD1 as a representative member that is localized in the mitochondrial matrix and functions as a molecular chaperone in an ATP-dependent manner (Singh et al., 2024a)

88 STAT3 forms complexes with TOX, directly binding promoters of inhibitory receptors such as PD-1, TIM-3, and LAG-3, increasing chromatin accessibility and enforcing an exhausted phenotype

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